Nootkatone is a citrus ingredient that is characteristically associated with grapefruit that has the potential to become an effective repellent against a range of insect pests including ticks, bed bugs and mosquitoes.
For example, the US Centers for Disease Control (CDC) has demonstrated that nootkatone is a highly effective agent against the ticks that transmit Lyme disease.
To view raw video footage of an untreated finger exposed to ticks vs a finger treated with nootkatone, please click here.
However, prior to initiating sales of insect control products that utilise nootkatone as an active ingredient, it will be necessary to obtain regulatory approval from the US Environmental Protection Agency (EPA) and similar governing bodies in other countries.
In 2015 the EPA has already ruled that nootkatone meets the standards for a bio-pesticide classification. This classification allows for a potentially expedited registration process. We are making good progress in this process, and given this continues, we expect approval in 2018. We are also working on regulatory approval of nootkatone in a number of other geographies.
In 2016 we signed an agreement with the CDC, which grants Evolva the exclusive worldwide patent rights to develop and commercialise nootkatone for the control of a wide range of disease and virus vectors such as ticks, mosquitoes, fleas, flies, lice, bed bugs, and other biting insects. In 2016 we also announced that the US National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), is sponsoring studies to test Evolva’s nootkatone against mosquitoes infected with Zika virus. The study focus is nootkatone in multiple formulations against wild type and insecticide-resistant mosquitoes that carry the virus.
During 2016 we worked with multiple potential customers, as well as on our own behalf, in demonstrating the utility of nootkatone against a wide range of insects and related pests. Part of this work involves the design of new repellent formulation against mosquitos, ticks and bed bugs.
Looking for a visual explanation of nootkatone? Find above our short animated video on nootkatone.