Scientific Publications

  1. Improving heterologous production of phenylpropanoids in Saccharomyces cerevisiae by tackling an unwanted side reaction of Tsc13, an endogenous double bond reductase.

Lehka BJ, Eichenberger M, Bjørn-Yoshimoto WE, Vanegas KG, Buijs N, Jensen NB, Dyekjær JD, Jenssen H, Simon E, Naesby M.

FEMS Yeast Res. 2017 Jan 10. pii: fox004. doi: 10.1093/femsyr/fox004. [Epub ahead of print]

PMID: 28073929 


  1. Improvement of whole-cell transamination with Saccharomyces cerevisiae using metabolic engineering and cell pre-adaptation.

Weber N, Gorwa-Grauslund M, Carlquist M.

Microb Cell Fact. 2017 Jan 3;16(1):3. doi: 10.1186/s12934-016-0615-3.

PMID: 28049528


  1. Microbial production of next-generation stevia sweeteners.

Olsson K, Carlsen S, Semmler A, Simón E, Mikkelsen MD, Møller BL.

Microb Cell Fact. 2016 Dec 7;15(1):207.

PMID: 27923373 


  1. Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties.

Eichenberger M, Lehka BJ, Folly C, Fischer D, Martens S, Simón E, Naesby M.

Metab Eng. 2016 Oct 31. pii: S1096-7176(16)30185-9. doi: 10.1016/j.ymben.2016.10.019. [Epub ahead of print]

PMID: 27810393


  1. Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast.

Skjoedt ML, Snoek T, Kildegaard KR, Arsovska D, Eichenberger M, Goedecke TJ, Rajkumar AS, Zhang J, Kristensen M, Lehka BJ, Siedler S, Borodina I, Jensen MK, Keasling JD.

Nat Chem Biol. 2016 Nov;12(11):951-958. doi: 10.1038/nchembio.2177.

PMID: 27642864


  1. New Genes Involved in Osmotic Stress Tolerance in <i>Saccharomyces cerevisiae</i>.

Gonzalez R, Morales P, Tronchoni J, Cordero-Bueso G, Vaudano E, Quirós M, Novo M, Torres-Pérez R, Valero E.

Front Microbiol. 2016 Sep 28;7:1545.

PMID: 27733850


  1. Identification of target genes to control acetate yield during aerobic fermentation with Saccharomyces cerevisiae.

Curiel JA, Salvadó Z, Tronchoni J, Morales P, Rodrigues AJ, Quirós M, Gonzalez R.

Microb Cell Fact. 2016 Sep 15;15(1):156. doi: 10.1186/s12934-016-0555-y.

PMID: 27627879


  1. Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

Luo D, Callari R, Hamberger B, Wubshet SG, Nielsen MT, Andersen-Ranberg J, Hallström BM, Cozzi F, Heider H, Lindberg Møller B, Staerk D, Hamberger B.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5082-9. doi: 10.1073/pnas.1607504113.

PMID: 27506796 


  1. Genomic and functional analyses unveil the response to hyphal wall stress in Candida albicans cells lacking β(1,3)-glucan remodeling.

Degani G, Ragni E, Botias P, Ravasio D, Calderon J, Pianezzola E, Rodriguez-Peña JM, Vanoni MA, Arroyo J, Fonzi WA, Popolo L.

BMC Genomics. 2016 Jul 2;17:482. doi: 10.1186/s12864-016-2853-5.

PMID: 27411447


  1. Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway.

Kildegaard KR, Jensen NB, Schneider K, Czarnotta E, Özdemir E, Klein T, Maury J, Ebert BE, Christensen HB, Chen Y, Kim IK, Herrgård MJ, Blank LM, Forster J, Nielsen J, Borodina I.

Microb Cell Fact. 2016 Mar 15;15:53. doi: 10.1186/s12934-016-0451-5.

PMID: 26980206


  1. Yeast-based assays for screening 11β-HSD1 inhibitors.

Vanella R, Callari R, Weston A, Heider H, Schwab MS, Kübler E.

Microb Cell Fact. 2016 Mar 15;15:52. doi: 10.1186/s12934-016-0450-6.

PMID: 26980090


  1. Increased availability of NADH in metabolically engineered baker’s yeast improves transaminase-oxidoreductase coupled asymmetric whole-cell bioconversion.

Knudsen JD, Hägglöf C, Weber N, Carlquist M.

Microb Cell Fact. 2016 Feb 15;15:37. doi: 10.1186/s12934-016-0430-x.

PMID: 26879378


  1. Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis.

Andersen-Ranberg J, Kongstad KT, Nielsen MT, Jensen NB, Pateraki I, Bach SS, Hamberger B, Zerbe P, Staerk D, Bohlmann J, Møller BL, Hamberger B.

Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2142-6. doi: 10.1002/anie.201510650.

PMID: 26749264


  1. Lotus japonicus flowers are defended by a cyanogenic β-glucosidase with highly restricted expression to essential reproductive organs.

Lai D, Pičmanová M, Abou Hachem M, Motawia MS, Olsen CE, Møller BL, Rook F, Takos AM.

Plant Mol Biol. 2015 Sep;89(1-2):21-34. doi: 10.1007/s11103-015-0348-4.

PMID: 26249044


  1. Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway-Enzymatic Formation of a Cyclopropyl Group.

Jakubczyk D, Caputi L, Hatsch A, Nielsen CA, Diefenbacher M, Klein J, Molt A, Schröder H, Cheng JZ, Naesby M, O’Connor SE.

Angew Chem Weinheim Bergstr Ger. 2015 Apr 20;127(17):5206-5210.

PMID: 27546918 


  1. Vanillin formation from ferulic acid in Vanilla planifolia is catalysed by a single enzyme.

Gallage NJ, Hansen EH, Kannangara R, Olsen CE, Motawia MS, Jørgensen K, Holme I, Hebelstrup K, Grisoni M, Møller BL.

Nat Commun. 2014 Jun 19;5:4037. doi: 10.1038/ncomms5037.

PMID: 24941968 


  1. Selection of non-Saccharomyces yeast strains for reducing alcohol levels in wine by sugar respiration.

Quirós M, Rojas V, Gonzalez R, Morales P.

Int J Food Microbiol. 2014 Jul 2;181:85-91. doi: 10.1016/j.ijfoodmicro.2014.04.024.

PMID: 24831930 


  1. Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery.

Klein J, Heal JR, Hamilton WD, Boussemghoune T, Tange TØ, Delegrange F, Jaeschke G, Hatsch A, Heim J.

ACS Synth Biol. 2014 May 16;3(5):314-23. doi: 10.1021/sb400177x.

PMID: 24742115 


  1. Controlled nail delivery of a novel lipophilic antifungal agent using various modern drug carrier systems as well as in vitro and ex vivo model systems.

Naumann S, Meyer JP, Kiesow A, Mrestani Y, Wohlrab J, Neubert RH.

J Control Release. 2014 Apr 28;180:60-70. doi: 10.1016/j.jconrel.2014.02.013.

PMID: 24560884 


  1. The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis.

Knechtle P, Diefenbacher M, Greve KB, Brianza F, Folly C, Heider H, Lone MA, Long L, Meyer JP, Roussel P, Ghannoum MA, Schneiter R, Sorensen AS.

Antimicrob Agents Chemother. 2014;58(1):455-66. doi: 10.1128/AAC.01443-13.

PMID: 24189258


  1. Genetic chemistry: production of non-native compounds in yeast.

Goldman S.

Curr Opin Chem Biol. 2010 Jun;14(3):390-5. doi: 10.1016/j.cbpa.2010.03.036. Review.

PMID: 20456999 


  1. Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae.

Naesby M, Nielsen SV, Nielsen CA, Green T, Tange TO, Simón E, Knechtle P, Hansson A, Schwab MS, Titiz O, Folly C, Archila RE, Maver M, van Sint Fiet S, Boussemghoune T, Janes M, Kumar AS, Sonkar SP, Mitra PP, Benjamin VA, Korrapati N, Suman I, Hansen EH, Thybo T, Goldsmith N, Sorensen AS.

Microb Cell Fact. 2009 Aug 13;8:45. doi: 10.1186/1475-2859-8-45.

PMID: 19678954 


  1. Substrate specificities of family 1 UGTs gained by domain swapping.

Hansen EH, Osmani SA, Kristensen C, Møller BL, Hansen J.

Phytochemistry. 2009 Mar;70(4):473-82. doi: 10.1016/j.phytochem.2009.01.013.

PMID: 19261311 

  1. The internal initiation of translation in bovine viral diarrhea virus RNA depends on the presence of an RNA pseudoknot upstream of the initiation codon.

Moes L, Wirth M.

Virol J. 2007 Nov 22;4:124.

PMID: 18034871


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