18 March 2019 – Reinach, Switzerland – Evolva (SIX: EVE) today announced the receipt of a letter from the US Environmental Protection Agency (EPA) shortly ahead of the expected regulatory registration.
In the course of its in-depth review of Evolva’s application to register nootkatone as a “manufacturing-use product” (MP), the Agency identified one study for which it could not complete its review and has requested further information.
Evolva is in close interaction with EPA to resolve the identified issue and to determine the next steps which will include extension of the regulatory deadline. Evolva will inform its stakeholders accordingly as soon as it will have gained more visibility.
Evolva remains fully committed to the project and is confident that nootkatone will be registered as an active ingredient against ticks and mosquitoes.
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Nootkatone is an ingredient found in minute quantities in the bark of the Alaska yellow cedar (also known as the Nootka cypress) and in the skin of grapefruit. It can also be produced on an industrial scale from brewing via yeast fermentation. Nootkatone has been tested against a variety of biting arthropods, including the ticks that are responsible for spreading Lyme disease and the mosquitoes that spread like Zika, chikungunya, dengue and West Nile viruses.
About Evolva’s collaboration with CDC and BARDA
This project has been funded with Federal funds from the Centers for Disease Control and Prevention (CDC), and managed by the Office of the Assistant Secretary for Preparedness and Response (ASPR), Biomedical Advanced Research and Development Authority (BARDA), under Contract No. HHSO100201700015C.
About Lyme disease and Zika virus
Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks (aka deer tick, Ixodes scapularis and Ixodes pacificus). Zika virus is spread to people primarily through the bite of an infected Aedes species mosquito (Ae. aegypti and Ae. albopictus). There is no vaccine or medicine for Zika; the best protection is to avoid mosquito bites.
About tick- and mosquito-borne illnesses in the US
Last year, the CDC issued a report stating that illnesses from mosquito, tick and flea bites tripled from 2004-2016. The report warned that better options are needed in the fight against these disease vectors. “Widespread and difficult to control diseases from mosquito, tick, and flea bites are major causes of sickness and death worldwide. The growing number and spread of these diseases pose an increasing risk in the U.S. The report found that the nation needs to be better prepared to face this public health threat.”