Applications and Benefits

Amongst the benefits of our approach are that it can:

• lead to compounds that are structurally differentiated from those obtained from conventional synthetic approaches;
• lead to compounds that are more rigid and have more complex stereochemistries than those obtained from conventional synthetic approaches – properties that can make the resultant compounds more active and specific;
• allow the discovery of compounds with new mechanisms of action, but without knowing the mechanism in advance;
• optimise compounds on function, not affinity, and simultaneously optimise on multiple properties; and
• select against toxic compounds or those with poor stability or distribution.