Scientific Publications

Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae.

Vanegas KG, Larsen AB, Eichenberger M, Fischer D, Mortensen UH, Naesby M.

Microb Cell Fact. 2018 Jul 9;17(1):107. doi: 10.1186/s12934-018-0952-5.

 

De novo biosynthesis of anthocyanins in Saccharomyces cerevisiae.

Eichenberger M, Hansson A, Fischer D, Dürr L, Naesby M.

FEMS Yeast Res. 2018 Jun 1;18(4). doi: 10.1093/femsyr/foy046.

 

Biosynthesis of angelyl-CoA in Saccharomyces cerevisiae.

Callari R, Fischer D, Heider H, Weber N.

Microb Cell Fact. 2018 May 12;17(1):72. doi: 10.1186/s12934-018-0925-8.

 

Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus.

Heskes AM, Sundram TCM, Boughton BA, Jensen NB, Hansen NL, Crocoll C, Cozzi F, Rasmussen S, Hamberger B, Hamberger B, Staerk D, Møller BL, Pateraki I.

Plant J. 2018 Mar;93(5):943-958. doi: 10.1111/tpj.13822. Epub 2018 Feb 14.

 

The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis.

Molero C, Casado C, Ariño J.

Sci Rep. 2017 Aug 18;7(1):8819. doi: 10.1038/s41598-017-09360-5.

 

Production of Putative Diterpene Carboxylic Acid Intermediates of Triptolide in Yeast.

Forman V, Callari R, Folly C, Heider H, Hamberger B.

Molecules. 2017 Jun 13;22(6). pii: E981. doi: 10.3390/molecules22060981.

 

Designing microorganisms for heterologous biosynthesis of cannabinoids.

Carvalho Â, Hansen EH, Kayser O, Carlsen S, Stehle F.

FEMS Yeast Res. 2017 Jun 1;17(4). doi: 10.1093/femsyr/fox037. Review.

 

Functional screening of aldehyde decarbonylases for long-chain alkane production by Saccharomyces cerevisiae.

Kang MK, Zhou YJ, Buijs NA, Nielsen J.

Microb Cell Fact. 2017 May 2;16(1):74. doi: 10.1186/s12934-017-0683-z.

 

Membrane potential independent transport of NH3 in the absence of ammonium permeases in Saccharomyces cerevisiae.

Cueto-Rojas HF, Milne N, van Helmond W, Pieterse MM, van Maris AJA, Daran JM, Wahl SA.

BMC Syst Biol. 2017 Apr 17;11(1):49. doi: 10.1186/s12918-016-0381-1.

 

Production of (S)-2-aminobutyric acid and (S)-2-aminobutanol in Saccharomyces cerevisiae.

Weber N, Hatsch A, Labagnere L, Heider H.

Microb Cell Fact. 2017 Mar 23;16(1):51. doi: 10.1186/s12934-017-0667-z.

 

Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii.

Pateraki I, Andersen-Ranberg J, Jensen NB, Wubshet SG, Heskes AM, Forman V, Hallström B, Hamberger B, Motawia MS, Olsen CE, Staerk D, Hansen J, Møller BL, Hamberger B.

Elife. 2017 Mar 14;6. pii: e23001. doi: 10.7554/eLife.23001.

 

Improving heterologous production of phenylpropanoids in Saccharomyces cerevisiae by tackling an unwanted side reaction of Tsc13, an endogenous double bond reductase.

Lehka BJ, Eichenberger M, Bjørn-Yoshimoto WE, Vanegas KG, Buijs N, Jensen NB, Dyekjær JD, Jenssen H, Simon E, Naesby M.

FEMS Yeast Res. 2017 Jan 10. pii: fox004. doi: 10.1093/femsyr/fox004. [Epub ahead of print]

PMID: 28073929 

 

 

Improvement of whole-cell transamination with Saccharomyces cerevisiae using metabolic engineering and cell pre-adaptation.

Weber N, Gorwa-Grauslund M, Carlquist M.

Microb Cell Fact. 2017 Jan 3;16(1):3. doi: 10.1186/s12934-016-0615-3.

PMID: 28049528

 

 

Microbial production of next-generation stevia sweeteners.

Olsson K, Carlsen S, Semmler A, Simón E, Mikkelsen MD, Møller BL.

Microb Cell Fact. 2016 Dec 7;15(1):207.

PMID: 27923373 

 

 

Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties.

Eichenberger M, Lehka BJ, Folly C, Fischer D, Martens S, Simón E, Naesby M.

Metab Eng. 2016 Oct 31. pii: S1096-7176(16)30185-9. doi: 10.1016/j.ymben.2016.10.019. [Epub ahead of print]

PMID: 27810393

 

 

Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast.

Skjoedt ML, Snoek T, Kildegaard KR, Arsovska D, Eichenberger M, Goedecke TJ, Rajkumar AS, Zhang J, Kristensen M, Lehka BJ, Siedler S, Borodina I, Jensen MK, Keasling JD.

Nat Chem Biol. 2016 Nov;12(11):951-958. doi: 10.1038/nchembio.2177.

PMID: 27642864

 

 

New Genes Involved in Osmotic Stress Tolerance in <i>Saccharomyces cerevisiae</i>.

Gonzalez R, Morales P, Tronchoni J, Cordero-Bueso G, Vaudano E, Quirós M, Novo M, Torres-Pérez R, Valero E.

Front Microbiol. 2016 Sep 28;7:1545.

PMID: 27733850

 

 

Identification of target genes to control acetate yield during aerobic fermentation with Saccharomyces cerevisiae.

Curiel JA, Salvadó Z, Tronchoni J, Morales P, Rodrigues AJ, Quirós M, Gonzalez R.

Microb Cell Fact. 2016 Sep 15;15(1):156. doi: 10.1186/s12934-016-0555-y.

PMID: 27627879

 

 

Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

Luo D, Callari R, Hamberger B, Wubshet SG, Nielsen MT, Andersen-Ranberg J, Hallström BM, Cozzi F, Heider H, Lindberg Møller B, Staerk D, Hamberger B.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5082-9. doi: 10.1073/pnas.1607504113.

PMID: 27506796 

 

 

Genomic and functional analyses unveil the response to hyphal wall stress in Candida albicans cells lacking β(1,3)-glucan remodeling.

Degani G, Ragni E, Botias P, Ravasio D, Calderon J, Pianezzola E, Rodriguez-Peña JM, Vanoni MA, Arroyo J, Fonzi WA, Popolo L.

BMC Genomics. 2016 Jul 2;17:482. doi: 10.1186/s12864-016-2853-5.

PMID: 27411447

 

 

Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway.

Kildegaard KR, Jensen NB, Schneider K, Czarnotta E, Özdemir E, Klein T, Maury J, Ebert BE, Christensen HB, Chen Y, Kim IK, Herrgård MJ, Blank LM, Forster J, Nielsen J, Borodina I.

Microb Cell Fact. 2016 Mar 15;15:53. doi: 10.1186/s12934-016-0451-5.

PMID: 26980206

 

 

Yeast-based assays for screening 11β-HSD1 inhibitors.

Vanella R, Callari R, Weston A, Heider H, Schwab MS, Kübler E.

Microb Cell Fact. 2016 Mar 15;15:52. doi: 10.1186/s12934-016-0450-6.

PMID: 26980090

 

 

Increased availability of NADH in metabolically engineered baker’s yeast improves transaminase-oxidoreductase coupled asymmetric whole-cell bioconversion.

Knudsen JD, Hägglöf C, Weber N, Carlquist M.

Microb Cell Fact. 2016 Feb 15;15:37. doi: 10.1186/s12934-016-0430-x.

PMID: 26879378

 

 

Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis.

Andersen-Ranberg J, Kongstad KT, Nielsen MT, Jensen NB, Pateraki I, Bach SS, Hamberger B, Zerbe P, Staerk D, Bohlmann J, Møller BL, Hamberger B.

Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2142-6. doi: 10.1002/anie.201510650.

PMID: 26749264

 

 

Lotus japonicus flowers are defended by a cyanogenic β-glucosidase with highly restricted expression to essential reproductive organs.

Lai D, Pičmanová M, Abou Hachem M, Motawia MS, Olsen CE, Møller BL, Rook F, Takos AM.

Plant Mol Biol. 2015 Sep;89(1-2):21-34. doi: 10.1007/s11103-015-0348-4.

PMID: 26249044

 

 

Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway-Enzymatic Formation of a Cyclopropyl Group.

Jakubczyk D, Caputi L, Hatsch A, Nielsen CA, Diefenbacher M, Klein J, Molt A, Schröder H, Cheng JZ, Naesby M, O’Connor SE.

Angew Chem Weinheim Bergstr Ger. 2015 Apr 20;127(17):5206-5210.

PMID: 27546918 

 

 

Vanillin formation from ferulic acid in Vanilla planifolia is catalysed by a single enzyme.

Gallage NJ, Hansen EH, Kannangara R, Olsen CE, Motawia MS, Jørgensen K, Holme I, Hebelstrup K, Grisoni M, Møller BL.

Nat Commun. 2014 Jun 19;5:4037. doi: 10.1038/ncomms5037.

PMID: 24941968 

 

 

Selection of non-Saccharomyces yeast strains for reducing alcohol levels in wine by sugar respiration.

Quirós M, Rojas V, Gonzalez R, Morales P.

Int J Food Microbiol. 2014 Jul 2;181:85-91. doi: 10.1016/j.ijfoodmicro.2014.04.024.

PMID: 24831930 

 

 

Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery.

Klein J, Heal JR, Hamilton WD, Boussemghoune T, Tange TØ, Delegrange F, Jaeschke G, Hatsch A, Heim J.

ACS Synth Biol. 2014 May 16;3(5):314-23. doi: 10.1021/sb400177x.

PMID: 24742115 

 

 

Controlled nail delivery of a novel lipophilic antifungal agent using various modern drug carrier systems as well as in vitro and ex vivo model systems.

Naumann S, Meyer JP, Kiesow A, Mrestani Y, Wohlrab J, Neubert RH.

J Control Release. 2014 Apr 28;180:60-70. doi: 10.1016/j.jconrel.2014.02.013.

PMID: 24560884 

 

 

The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis.

Knechtle P, Diefenbacher M, Greve KB, Brianza F, Folly C, Heider H, Lone MA, Long L, Meyer JP, Roussel P, Ghannoum MA, Schneiter R, Sorensen AS.

Antimicrob Agents Chemother. 2014;58(1):455-66. doi: 10.1128/AAC.01443-13.

PMID: 24189258

 

 

Genetic chemistry: production of non-native compounds in yeast.

Goldman S.

Curr Opin Chem Biol. 2010 Jun;14(3):390-5. doi: 10.1016/j.cbpa.2010.03.036. Review.

PMID: 20456999 

 

 

Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae.

Naesby M, Nielsen SV, Nielsen CA, Green T, Tange TO, Simón E, Knechtle P, Hansson A, Schwab MS, Titiz O, Folly C, Archila RE, Maver M, van Sint Fiet S, Boussemghoune T, Janes M, Kumar AS, Sonkar SP, Mitra PP, Benjamin VA, Korrapati N, Suman I, Hansen EH, Thybo T, Goldsmith N, Sorensen AS.

Microb Cell Fact. 2009 Aug 13;8:45. doi: 10.1186/1475-2859-8-45.

PMID: 19678954 

 

 

Substrate specificities of family 1 UGTs gained by domain swapping.

Hansen EH, Osmani SA, Kristensen C, Møller BL, Hansen J.

Phytochemistry. 2009 Mar;70(4):473-82. doi: 10.1016/j.phytochem.2009.01.013.

PMID: 19261311 

 

The internal initiation of translation in bovine viral diarrhea virus RNA depends on the presence of an RNA pseudoknot upstream of the initiation codon.

Moes L, Wirth M.

Virol J. 2007 Nov 22;4:124.

PMID: 18034871

 

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