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Our resveratrol. Better, naturally.

Our resveratrol is manufactured with a unique and patented fermentation process resulting in a product with over 98% purity and of uncompromised quality.

The highest purity, quality and availability

Our unique fermentation technology and process results in resveratrol with a purity over 98%.

Stringent controls and testing ensures that our resveratrol is always manufactured and delivered at a consistently high standard quality.

Our product is always readily available. How do we achieve this?

By fermenting resveratrol we overcome common supply chain issues caused by the crop shortages that result from variable weather, disease and drought.

Our resveratrol is a high-purity (> 98%) trans-Resveratrol made by fermentation, resulting in a consistent and traceable product without the challenges and variability of plant-derived extracts. Free of common impurities like emodin (a laxative), pesticides and herbicides.

The Importance of High-Purity Resveratrol

Most resveratrol products are made from Japanese knotweed extracts standardized to 20-50% Resveratrol, or grape extracts containing very little resveratrol (~5-10%). Standardized extracts are subject to seasonal, and batch-to-batch variations.

The quality of these extracts can be difficult to control, and a significant portion of the extract composition remains entirely uncharacterized. Studies on crude extracts can be difficult to interpret and reproduce, and results confounded by unwanted impurities.

Safety

  • Self-affirmed GRAS status in the US for dietary supplements and functional foods applications
  • European Novel Foods approval by substantial equivalence
  • No emodin or any other anthraquinones causing digestive discomfort
  • Pesticide-, herbicide-, PAH4-, and allergen-free
  • Not from chemical synthesis or the invasive Japanese knotweed
  • Free of any known skin irritants and allergens
  • Preferred Supplier Status from the National Animal Supplement Council (NASC)

Benefits

Numerous scientific publications and a growing body of clinical research support resveratrol’s role in healthy ageing. Its health benefits include:

  • Maintenance of a healthy cardiovascular system
  • Support of healthy blood glucose, insulin and blood pressure levels
  • Increases bone density in humans
  • Maintenance of healthy neurocognitive function
  • Reduction of oxidative damage common with ageing
Health benefits

A new ingredient for bone health

Resveratrol has been shown to support bone health through different mechanisms:

  • It can maintain the balance between bone resorption and bone formation
  • Reduce oxidative damage in the bones
  • Anti-inflammatory properties – a potential benefit for joint health

There is a limited choice of natural products supported by clinical evidence to help reduce the risk factors for osteoporosis. Our resveratrol is a high-purity, safe and affordable ingredient suitable for management of bone health.

Bone health, a matter of balance

The delicate balance between bone formation and bone resorption is lost with ageing, where bone resorption overtakes bone formation, which may result in low bone density and osteoporosis.1

One in three consumers are concerned about osteoporosis and want to improve their
bone health.2

References

  1. Mobasheri A and Shakibaei M. Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosis. Ann NY Acad Sci 2013;1290:59–66.
  2. Canadean 2015 report: Global and Regional Mega-Trends: Understanding Consumer Attitudes and Behaviors in Health and Wellness. Available from: Canadeanreportstore

Other related publications

Artsi H, Cohen-Kfir E, Gurt I, et al. The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice. Endocrinology 2014;155:3508–3515.

Boissy P, Andersen TL, Abdallah BM, et al. Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation. Cancer Res 2005;65:9943–9952.

Dai Z, Li Y, Quarles LD, et al. Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation. Phytomedicine 2007;14(12):806–814.

Del Fattore A, Teti A and Rucci N. Bone cells and the mechanisms of bone remodelling. Front Biosci 2012;4:2302–2321.

Durbin SM, Jackson JR, Ryan MJ, et al. Resveratrol supplementation influences bone properties in the tibia of hindlimb-suspended mature Fisher 344 x Brown Norway male rats. Appl Physiol Nutr Metab 2012;37:1179–1188.

Elmali N, Esenkaya I, Harma A, et al. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm Res. 2005;54(4):158–162.

Feng J, Liu S, Ma S, et al. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-kB signaling pathway. Acta Biochim Biophys Sin 2014;46:1024–1033.

Ginaldi L, Di Benedetto MC and De Martinis M. Osteoporosis, inflammation and ageing. Immunity & Ageing 2005;2:14.

IOM (Institute of Medicine). 2011. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press.

Johnson M, Fischer J, Bowman B, et al. Iron nutriture in elderly individuals. FASEB J 1994;8:609–621.

Lane NE. Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol 2006;194:S3–S11.

Lin JT and Lane JM. Osteoporosis: a review. Clin Orthop Relat Res 2004;425:126-134.

Ming L, Ji-guo W, De-ming X, et al. Resveratrol inhibits interleukin 1ß-mediated inductible nitric oxide synthase expression in articular chondrocytes by activating Sirt1 and thereby suppressing nuclear factor-kB activity. Eur J Pharmacol 2012;674:73–79.

Mizutani K, Ikeda K, Kawai Y, et al. Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun 1998;253(3):859-863.

Ornstrup MJ, Harsløf T, Kjær TN, et al. Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. J Clin Endocrinol Metab 2014;99(12):4720–4729.

Poulsen MM, Ornstrup MJ, Harsløf T, et al. Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men. J Funct Foods 2014;6:305–310.

Sehmisch S, Hammer F, Christoffel J, et al. Comparison of the phytohormones genistein, resveratrol and 8-prenylnaringenin as agents for preventing osteoporosis. Planta Med 2008;74(8):794–801.

Shakibaei M, Buhrmann C and Mobasheri A. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NFkappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem 2011;286:11492–11505.

Tou JC. Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy. Biochim Biophys Acta 2014;1852(6):1186–1194.

World Health Organization (2007) Assessment of osteoporosis at the primary health care level. Summary Report of a WHO Scientific Group. WHO, Geneva. Available from: www.who.int/chp/topics/rheumatic/en/index.html (Accessed August 2015).

Yang Q, Jian J, Abramson SB, et al. Inhibitory effects of iron on bone morphogenetic protein 2-induced osteoblastogenesis. J Bone Miner Res 2011;26:1188–1196.

Zhao L, Wang Y, Wang Z, et al. Effects of dietary resveratrol on excess-iron-induced bone loss via antioxidative character. J Nutr Biochem 2015;26(11):1174-1182.

Zhou H, Shang L, Li X, et al. Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells. Exp Cell Res 2009;315(17):2953–2962.

Zou T, Yang Y, Xia F, et al. Resveratrol inhibits CD4+ T cell activation by enhancing the expression and activity of Sirt1. PLoS ONE 2013;8(9):e75139.

Blood glucose control - benefits of resveratrol

Clinical studies show that resveratrol:

  • Helps control blood glucose levels
  • May improve insulin sensitivity
  • May reduce risk factors in prediabetes
  • Possesses an excellent safety profile and no observed drug interactions

Reduce insulin levels

Many people with diabetes either develop resistance to insulin or their body does not produce enough insulin. In a double-blind, placebo-controlled study of men diagnosed with type 2 diabetes (n=19), 4 weeks of treatment with low-dose resveratrol (2x5mg) was found to significantly reduce insulin resistance, thus improving insulin sensitivity.1 This appeared to decrease blood glucose levels and delay peaks in blood glucose after meals.

Diabetes and the drive for healthy blood glucose control

With diabetes rates rising, people are increasingly seeking new solutions to help maintain healthy blood glucose levels. Although dietary supplements are widely used in the management of blood glucose, there are few well-documented natural products currently available.

There is significant interest in the potential health benefits of resveratrol in helping to maintain healthy blood glucose levels.

Reference

  1. Brasnyo P, Molnar BA, Mohas M, et al. Resveratrol improves insulin sensitivity,
    reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.
    Br J Nutr 2011;106(3):383-389.

Other related publications

Agarwal B and Baur JA. Resveratrol and life extension. Ann N Y Acad Sci 2011;1215:138-143.

Bhatt JK, Thomas S and Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res 2012;32:53-541.

Crandall JP, Oram V, Trandafirescu G, et al. Pilot study of resveratrol in older adults with impaired glucose tolerance. J Gerontol A Biol Sci Med Sci 2012;67(12):1307-1312.

Farimani AR, Saidijam M, Goodarzi MT, et al. Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats. Iran J Med Sci 2015;40(3):248-255.

Lagouge M, Argman C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006;127(6):1109-1122.

Liu K, Zhou R, Wang B and Mi M-T. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr 2014;99(6):1510-1519.

Movahed A, Nabipour I, Lieben Louis X, et al. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Alternat Med 2013; Article ID 851267,2013. doi:10.1155/2013/851267.

Sun C, Zhang F, Ge X, et al. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab 2007;6(4):307-319.

Sun L, Wang Y, Song Y, et al. Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice. Biochem Biophys Res Comm 2015;458:86-91.

Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011;14(5): 612-622.

US Centers for Disease Control and Prevention. Diabetes 2014 report card. Available from: www.cdc.gov/diabetes/library/reports/congress.html. Accessed September 2015.

World Health Organization. Diabetes. Fact sheet N° 312. January 2015. Available from: www.who.int/mediacentre/factsheets/fs312/en/ Accessed September 2015.

Yun JM, Chien A, Jialal I and Devaraj S. Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights. J Nutr Biochem 2012;23(7):699-705.

Support for good cardiovascular health

There is a growing demand for solutions that can help reduce the risk factors for cardiovascular disease (CVD).1

Some of the most common types of CVD include:2

  • Coronary heart disease
  • Cerebrovascular disease (eg. stroke)
  • Hypertension
  • Peripheral vascular disease, narrowing of blood vessels outside of the heart and brain, e.g. in the legs3

The risk of CVD increases with age,4 but lifestyle changes can reduce the risk of most CVDs.1 Recommended lifestyle changes include a healthy diet, exercising regularly, reducing alcohol intake and not smoking.1

Although dietary supplements claiming benefits for cardiovascular health are widely used, few of them are supported by clinical evidence.

Resveratrol is a new way to support cardiovascular health

Resveratrol is a natural ingredient with a range of potential CVD benefits. It has shown in clinical studies to lower systolic blood pressure, improve blood flow and reduce risk of CVD. Resveratrol may be effective as supplementation therapy and has an excellent safety profile.

With few well-documented natural products available, resveratrol offers a strong evidence base for its potential use in the support of cardiovascular health.

References

  1. World Health Organization. Cardiovascular diseases (CVDs). Fact sheet N°317. January
    2015. Available from: www.who.int/mediacentre/factsheets/fs317/en/ Accessed September 2015.
  2. Global Atlas on Cardiovascular Disease Prevention and Control. Mendis S et al. eds. World Health Organization, Geneva 2011.
  3. World Health Organization. Tobacco Free Initiative (TFI). Peripheral vascular disease.
    Available from: www.who.int/tobacco/research/pagetld21/en/ Accessed September 2015.
  4. World Health Organization 2009. Global health risks: mortality and burden of disease attributable to selected major risks.

Other related publications

Black CD, Vickerson B and McCully KK. Noninvasive assessment of vascular function in the posterior tibial artery of healthy humans. Dynamic Med 2003;2:1.

Carrizzo A, Puca A, Damato A, et al. Resveratrol Improves Vascular Function in Patients With Hypertension and Dyslipidemia by Modulating NO Metabolism. Hypertension 2013;62(2):359-366.

Collins R and MacMahon S. Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease. Br Med Bull 1994;50(2):272-298.

Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360(9349):1903-1913.

Liu Y, Ma W, Zhang P, et al. Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials. Clin Nutr 2015;34(1):27-34.

Militaru C, Donoiu I, Craciun A, et al. Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life. Nutrition 2013;29(1):178-183.

Movahed A, Nabipour I, Lieben Louis X, et al. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Alternat Med 2013; Article ID 851267,2013. doi:10.1155/2013/851267.

Petrovski G, Gurusamy N and Das DK. Resveratrol in cardiovascular health and disease. Ann N Y Acad Sci 2011;1215:22-33.

Strandberg TE and Pitkala K. What is the most important component of blood pressure: systolic, diastolic or pulse pressure? Curr Opin Nephrol Hypertens 2003;12(3): 293-297.

Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011;14(5):612-622.

Tomé-Carneiro J, Gonzalvez M, Larrosa M, et al. Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease. Cardiovasc Drugs Ther 2013;27(1):37-48.

Tomé-Carneiro J, Gonzalvez M, Larrosa M, et al. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol 2012;110:356-363.

Wong RH, Howe PR, Buckley JD, et al. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis 2011;21(11):851-856.

Products

Resveratrol

Resveratrol is the functional ingredient in red wine that you’ve been hearing about. Many of the beneficial effects of resveratrol are thought to be mediated via its induction of “survival” genes and its inhibition of certain pro-inflammatory pathways. These actions result in the rejuvenation of many systems that begin to fail as we age.

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Registering to our online shop allows you to view all product specifications and place orders. You can also access information such as technical data sheets for our products, legal guidelines and labelling documents. Get your FREE resveratrol sample now.

Our Resveratrol

10773

Minimum 98% pure resveratrol produced by yeast fermentation. This is a resveratrol product you can trust to deliver a consistently high quality natural ingredient. Off-white in colour, odourless and tasteless making it very versatile for formulation.

  • Package sizePrice
  • Sample 10 gFree
  • 100 gOn request
  • 1 KgOn request
  • 5 KgOn request
  • Bulk quantities on request

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