Resveratrol

Resveratrol (see also res.evolva.com) is a natural plant ingredient belonging to the family of polyphenols and is associated with a range of beneficial effects. In the public mind it is perhaps most associated with red wine. However, the amounts in red wine (approx. 1mg/glass, though it varies a lot) are too low to be beneficial (most studies suggest you need 50-150mg/day of resveratrol to see such effects).

Many of the beneficial effects of resveratrol (such as the way it mimics the effects of a calorie-restricted diet) are thought to be mediated via its induction of “survival” genes. Resveratol also directly inhibits certain pro-inflammatory pathways and is an antioxidant.

Resveratrol has been widely studied, with some 6,000 papers published to date. Whilst it is perhaps most famous for driving significant extensions in life-span in animals, such effects have never been shown in humans. However, many studies in humans have shown positive effects on a wide variety of age-related health indications. A thorough review of the resveratrol literature by Novelle et al. was recently (January 2015) published in Ageing Research Reviews.

Most resveratrol on the market today comes from the roots of the Japanese knotweed plant (Polygonum cuspidatum), an invasive weed, possession of which is illegal in many countries. A small amount is made by synthetic chemistry, and an even smaller amount is extracted from grapes.

Evolva’s resveratrol is produced by yeast fermentation. It is an isomerically pure product that is free of pesticides and other impurities that are frequently found in knotweed extracts. It is made from natural and sustainable feedstocks and has a stable, traceable and reliable supply chain.

Evolva’s resveratrol has Self-Affirmed GRAS status in the United States and Novel Foods Authorisation for use in Dietary Supplements in the EU.

As with all Evolva’s products, it is hard to estimate the market potential of Evolva’s resveratrol. A 2012 report by Frost & Sullivan estimated total resveratrol sales at some USD 50 million, with the vast majority being used in nutritional supplements and with North America representing around 90% of sales. Evolva believes there is potential to grow the use of resveratrol in nutritional supplements, but also that resveratrol has the potential to be used in other areas, such as animal health, cosmetics and medical nutrition. Given successful growth into such applications, Evolva estimates that the total addressable market for its resveratrol may amount to around USD 400 million.

2014 activities & future plans

In 2014, Evolva successfully scaled up manufacture, making commercial product via a contract manufacturer in North America. Evolva launched resveratrol at the Supply Side West Expo in Las Vegas in October, making it Evolva’s first commercial product. Several distributor agreements were signed, with a focus on dietary supplements. Sales and interest met expectations. A dedicated website was established at res.evolva.com. During 2014, Evolva supplied material to a number of clinical and academic researchers who are studying the benefits and properties of resveratrol, and in December, Evolva sponsored the 2014 International Resveratrol Conference, bringing together leading researchers in the field.

In 2014, the first human study using Evolva’s resveratrol found that it improved bone health indicators such as bone density, bone formation and resorption in middle-aged men. (Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial).

In 2015, we intend to sign additional distributors and widen both the geographic and product range that our resveratrol is sold into. Evolva will also continue to work on getting regulatory approval for Evolva’s resveratrol in countries outside North America and Europe. Evolva’s resveratrol will be showcased at major food ingredient events, with an initial focus on our current main markets, the EU and US. We will continue to develop data on resveratrol working with the clinical and academic community, and to work on improving the manufacturing efficiency of the product.

For Commercial and Scientific Affairs inquiries please contact:

Evolva U.S.A / R.O.W +1 800 250 1032
Evolva Europe +41 61 485 2099
E-mail res [at] evolva.com
Website res.evolva.com

Further reading:
- Liu et. al.; Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials
- Website of Oregon State University
- David Sinclair, Harvard Medical School’s interview published by Science Friday
- Journal of Clinical Endocrinology & Metabolism; Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial

Contact Information

Evolva SA
Duggingerstrasse 23
CH-4153 Reinach
Switzerland
Tel: +41 61 485 2000
Fax: +41 61 485 2001
Evolva A/S
Lersoe Parkallé 42-44
DK-2100 Copenhagen OE
Denmark
Tel: +45 35 200 230
Fax: +45 35 200 231
Evolva Biotech Private Limited
401 - 405, 4th Floor
Ticel Bio Park Ltd
Taramani Road, Taramani
Chennai 600 113
Tamil Nadu, India
Tel: +91 44 4297 1050
Fax: +91 44 4297 1060
Evolva, Inc. (Evolva USA)
2440 Embarcadero Way
Palo Alto
CA 94303
USA
Tel: +1 650 856 2436
Fax: +1 650 856 7950

General Enquiries: info@evolva.com • Business Enquiries: busdev@evolva.com • India Enquiries: info_india@evolva.com