Resveratrol

Resveratrol

Resveratrol (see also res.evolva.com) is a natural compound produced in grapes and other plants as a response against environmental stress factors. It occurs in red wine, but at low concentrations. Scientific research has shown it to have many protective benefits against several health conditions related to aging. It is often mentioned as an explanation of the “French Paradox”. The “French Paradox” refers to the observation that mortality from coronary heart disease is relatively low in France despite relatively high levels of dietary saturated fat and cigarette smoking, leading to the idea that regular consumption of red wine might provide additional protection from cardiovascular disease.

Evolva’s resveratrol is produced by fermentation in yeast. Compared to plant extracts, this production route has the advantage that there is no risk of contamination with pesticides or heavy metals. It is also possible to create a high purity product.

Further reading:
- Liu et. al.; Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials
- Website of Oregon State University
- David Sinclair, Harvard Medical School’s interview published by Science Friday
- Journal of Clinical Endocrinology & Metabolism; Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial

Market opportunity

Today, by far the largest use of resveratrol is in dietary supplements. Based on multiple sources, Evolva believes resveratrol sales in dietary supplements have a retail value of around USD 40 – 60 million today but that there is considerable room for expansion as the market is still in its infancy. Over time Evolva believes resveratrol could also be used in food and beverage products, personal care and animal nutrition categories leading to a total addressable market (i.e. the size of the total market in which Evolva’s resveratrol will compete) of USD 400 million.

As compared to other resveratrol sources, Evolva’s product has the benefits of being the only high-purity natural resveratrol, from a traceable and easily scalable supply chain, free of any pesticides, with (over time) the lowest production costs. In addition, Evolva’s product is kosher and halal-certifiable, and has a neutral colour, odour, and taste. This enables the easy formulation and use of this ingredient in a variety of common food and beverage applications. In contrast to synthetic resveratrol, Evolva believes that its resveratrol addresses an increasing consumer demand for high-quality, trustworthy and affordable products that are considered “natural”.

Status and Plans

Evolva acquired its resveratrol product from Fluxome Sciences A/S (Denmark) (‘‘Fluxome’’) in November 2012. The Fluxome product has been on the US market since 2010, but primarily due to Fluxome’s high production costs has not generated significant sales. It has Self-Affirmed GRAS (“Generally Recognised As Safe”) status in the United States and obtained Novel Foods authorisation from the European Commission in January 2012 through the notification procedure. A ruling in 2013 by the Japanese Ministry of Health, Labor and Welfare is expected to facilitate the approval process for the product in Japan.

Since acquiring the programme Evolva has made excellent progress in reducing production costs and preparing the product for a commercial re-launch in the second half of 2014. Work on further reducing production costs will continue post-launch. We are in discussion with both distributors and specialty ingredient companies on how to accelerate sales post-launch.

For Commercial and Scientific Affairs inquiries please contact:

Evolva U.S.A / R.O.W +1 800 250 1032
Evolva Europe +41 61 485 2099
E-mail res@evolva.com
Website res.evolva.com

Contact Information

Evolva SA
Duggingerstrasse 23
CH-4153 Reinach
Switzerland
Tel: +41 61 485 2000
Fax: +41 61 485 2001
Evolva A/S
Lersoe Parkallé 42-44
DK-2100 Copenhagen OE
Denmark
Tel: +45 35 200 230
Fax: +45 35 200 231
Evolva Biotech Private Limited
401 - 405, 4th Floor
Ticel Bio Park Ltd
Taramani Road, Taramani
Chennai 600 113
Tamil Nadu, India
Tel: +91 44 4297 1050
Fax: +91 44 4297 1060
Evolva, Inc. (Evolva USA)
2440 Embarcadero Way
Palo Alto
CA 94303
USA
Tel: +1 650 856 2436
Fax: +1 650 856 7950

General Enquiries: info@evolva.com • Business Enquiries: busdev@evolva.com • India Enquiries: info_india@evolva.com