Evolva’s antibiotic EV-035 selected for an oral presentation at key scientific congress ICAAC

10. Sep 2012

Reinach, Switzerland, 10 September 2012 – Evolva Holding SA (SIX: EVE) presented extensive preclinical data on EV-035 at ICAAC, the world’s premier international conference on antimicrobial agents and infectious diseases. Professor Jutta Heim, CSO of Evolva, was invited by an ASM expert panel to summarise EV-035 as one of the key new compounds in the oral “Poster Summary Session” at ICAAC on Sunday. Preclinical data on the compound show a broad spectrum of activity against some of the most challenging bacteria, sometimes referred to as ‘Superbugs’. The four discussed posters will be available on Evolva’s website.

In vitro and in vivo data show the compound boasts strong efficacy in combatting bacteria that have become resistant to many of the older generations of antibiotics. The compound’s spectrum includes both Gram-positive and Gram-negative strains, including those resistant to quinolones. EV-035 is particularly potent against Enterococcus, Pseudomonas, Burkholderia and Staphylococcus. In preclinical MRSA models, oral doses of the compound reduced the number of bacteria by 5-6 logs in 24 hours, compared with 2.7 and 2.3 logs for intravenous vancomycin and ciprofloxacin (currently marketed antibiotics), respectively. MRSA (methicillin-resistant Staphylococcus aureus) is a particularly dangerous bacterium as it has developed resistance to almost all current antibiotics. ADMET data reveal EV-035 as well tolerated with no adverse effects in preclinical safety parameters. Good oral bioavailability and a large volume of distribution (in mouse models) warrant exploitation of EV-035 in major bacterial disease indications, including those of intracellular pathogens.

In addition, EV-035 dramatically increased survival rates in preclinical melioidosis models. This disease is endemic in large parts of Asia and is also seen as a possible bio-terrorist threat by the US Department of Defense, which supported some of the studies on EV-035.

Neil Goldsmith, CEO of Evolva commented, “Rising bacterial resistance and bio-terrorist threats pose pressing challenges. The data Evolva has presented at ICAAC today confirm the potential of EV-035 in addressing these challenges. We are thrilled by the fact that leading experts in this field selected EV-035 to be highlighted at this important conference.”

The following posters on EV-035 are displayed at 2012 ICAAC (Session 248: F-2030-F-2033)

  • EV-035: Novel 2-pyridone based topoisomerase inhibitors with broad-spectrum activity against MDR pathogens, including quinolone resistance
  • EV-035: in vitro ADMET, mouse PK and efficacy in murine infection models of a new orally available class of antibiotics
  • EV-035: Synthesis and in vitro antibacterial activity of a new series of 2-pyridone based topoisomerase inhibitors
  • EV-035: Potent antibiotic series against biothreat agent Burkholderia pseudomallei

 

– Ends –

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About Evolva

Evolva’s mission is to discover and provide innovative, sustainable ingredients for health, nutrition and wellness. Evolva uses biosynthetic and evolutionary technologies to create and optimise small molecule compounds and their production routes. We are active in consumer healthcare and nutrition as well as in pharma. In both areas we have partnered projects as well as proprietary programmes. For more information see www.evolva.com.

 

Contact Details
Evolva

Neil Goldsmith
CEO
[email protected]
+ 41 61 485 2005
Jakob Dynnes Hansen
CFO
[email protected]
+ 41 61 485 2034
Paul Verbraeken
IR
[email protected]
+ 41 61 485 2035

This press release contains specific forward-looking statements, e.g. statements including terms like believe, assume, expect or similar expressions. Such forward-looking statements are subject to known and unknown risks, uncertainties and other factors which may result in a substantial divergence between the actual results, financial situation, development or performance of the company and those explicitly or implicitly presumed in these statements. Against the background of these uncertainties readers should not place undue reliance on forward-looking statements. The company assumes no responsibility to update forward-looking statements or to adapt them to future events or developments.

Glossary Melioidosis
An infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei, found in soil and water. It is endemic in parts of southeast Asia (including Thailand, Laos and southern China, Singapore, Malaysia, Burma and Vietnam), Taiwan and northern Australia. Without proper antibiotic treatment, the disease could be fatal.
Gram-positive/ negative
Bacteria are traditionally divided into two main groups, Gram-positive and Gram-negative. Gram-positive cell walls typically lack the outer membrane found in Gram-negative bacteria.
Quinolone
A family of broad-spectrum antibiotics, nowadays threatened by global development of bacterial resistance.

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