Disclosure of Shareholdings

A full list of past disclosure is available on the website of SIX Swiss Exchange. The most recent disclosures are listed below.

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• October 2011 - YA Global
• September 2011 - Aravis
• September 2011 - Wellington
• September 2011 - Abunda SR
• September 2011 - Auriga
• September 2011 - Sunstone
• September 2011 - Novartis
• September 2011 - Entrepreneurs Fund
• September 2011 - Renaissance
• September 2011 - Mona Lisa
• September 2011 - Coordinated sale group

• September 2011 - Lockup Group

• 18 August 2011 - Evolva disposal positions

• 18 August 2011 - YA Global
• 15 July 2011 - Abunda
• 14 July 2011 - Evolva disposal positions
• 13 July 2011 - Sunstone
• 13 July 2011 - Aravis
• 13 July 2011 - Lock-up group

• 13 July 2011 - Coordinated sale group

• 8 June 2011 - Lock-up group

• 8 June 2011 - Coordinated sale group

• 8 June 2011 - Dansk Innovationsinvestering

• 27 May 2011 - Lock-up group

• 27 May 2011 - Coordinated sale group
• 27 May 2011 - Aravis
• 27 May 2011 - Auriga
• 27 May 2011 - Dansk Innovationsinvestering
• 27 May 2011 - Wellington Partners
• 27 May 2011 - Renaissance/Mona Lisa
• 27 May 2011 - Sunstone

• 26 May 2011 - Abunda

• 17 December 2010 - Lock-up group

• 17 December 2010 - Coordinated sale group