Ergot Alkaloids are a family of natural products made by certain fungi (“ergots”). Some are of potential use in crop protection whilst others are used as pharmaceuticals.

In 2011, Evolva entered a partnership with BASF (Ludwigshafen, Germany) to develop a fermentation route to certain ergot alkaloids of potential use in crop protection. BASF paid Evolva upfront and research fees. In 2013, Evolva successfully completed its initial part of the collaboration by transferring a strain to BASF. Since then BASF has been developing the products. Two peer reviewed papers relating to this collaboration have been published.

If BASF’s products reach market then Evolva is due royalties from BASF. In addition, Evolva may potentially earn revenues from commercialising other ergot alkaloids.

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    Published: the cycloclavine biosynthetic pathway revealed and reconstituted yields the enzymatic formation of a cyclopropyl group.

    Angewandte Chemie
  • Why ‘Natural’ doesn’t mean anything anymore

    Respected food politics thinker and academic, Michael Pollan, explains the deep flaw in our thinking about what is and what is not "natural".

    The New York Times
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